October 2023  24th Edition
A Message from the Dean

Dear colleagues,

The seasons are changing, students are back on campus and the whirl of fall activities has begun!

 
Discover Row 1
UCI Receives $5.8 Million NIH Grant for Acupuncture Research Database and Repository
A new open-access repository and database for acupuncture research called TARA (Topological Atlas and Repository for Acupoint research) will create an important bridge between traditional East Asian medical theories and modern understanding of anatomy and physiology.
 
UC Irvine to lead multi-institutional study of single-cell vulnerabilities to Alzheimer’s disease
Campus awarded $10 million NIH grant to analyze early-stage impact of tau protein deposits.
 
Discover Row 2
UCI awarded $3.5 million grant to study sex-specific brain pathway responses to stress
Building on the earlier discovery of how brain circuit operation is disrupted by exposure to early-life adversity, researchers will study the emergence of gender as a pivotal factor.
 
UCI awarded $3.8 million NIH grant to advance BRAIN Initiative research
Funding will help campus become a national center for neuroscience resources.
 
Discover Row 3
Researchers have discovered small-molecule drugs with potential clinical utility in the treatment of
age-related macular degeneration (AMD), diabetic retinopathy (DR) and retinitis pigmentosa (RP)
Today, approximately 350 million people worldwide suffer from debilitating vision loss caused by either AMD or DR, and a large majority of these cases (>90%) have only minimally effective or no treatment options available.
 
A UCI-led study found that plant extracts used by indigenous people hold promise in treatment of ataxia
Common nettle (Urtica dioica), one of the plants used in Native American traditional ataxia therapy and found in the present study to rescue EA1-linked mutant channel activity.
 
Discover 1 Article Rows
Foundation continues support for brain cancer research
Since 2021, when The Audley Fund of the Philadelphia Foundation began providing support, UCI Health neuro-oncologist Dr. Daniela Bota has led 29 innovative drug and vaccine trials.
 
New research may explain why, despite “the munchies,” frequent
cannabis users are leaner than non-users
Results show that interfering with endocannabinoid signaling during adolescence disrupts adipose organ function in a permanent way, with potentially far-reaching consequences on physical and mental health.
 
Teach Row 1
UCI named one of CIRM’s cell and gene therapy manufacturing facilities
A $2 million state grant allows campus stem cell center to advance regenerative medicine.
 
Devon Lawson, PhD, and Kai Kessenbrock, PhD, participate in milestone Human Breast Cell Atlas Project
The milestone project is the largest-ever atlas of normal breast cells, providing an unprecedented new resource for investigators working to understand changes that occur in the tissue during cancer and other diseases of the breast.
 
Teach Row 2
Simple sugar compound improves function in multiple sclerosis patients, a UCI study shows
Future studies demonstrating that N-acetylglucosamine can restore neuro-logical function in MS patients would be a game changer. 
 
School of Medicine Alumnus Donates $2 Million to New UCI Health — Irvine Building
Nicolas R. Conway, DO, dedicated nearly four decades to his private family medicine practice in California before retiring in 1988.
 
Teach Row 3
Bilingual, digital health tool helps reduce alcohol use, UC Irvine-led study finds
A large-scale, randomized clinical trial is the first of its kind focused on Latino participants. 
 
GLP-1RA weight-loss drugs may be dangerous to children, UCI researchers warn
Researchers say pediatric obesity has become epidemic in large measure because of environments without adequate venues for safe play and exercise for children and adolescents, coupled with the availability of popular, inexpensive, high-calorie fast-foods. 
 
Teach 1 Article Rows
Research team identifies glycosylation enzyme critical in brain formation
Findings may contribute to new therapeutic uses for neural stem cells.
 
2023 UCI School of Medicine White Coat Ceremony
The doctors-to-be also recited the medical student oath and received a pin from the Arnold P. Gold Foundation, signifying the importance of compassion and empathy in patient care.
 
Yuan-Chen Tsai, PhD, receives 2023 FRAXA Fellowship
Fragile X Syndrome (FXS) is the most common inherited cause of Autism and other neurological disorders and occurs when a single gene shuts down in the X chromosome. As a result, this gene does not form the protein needed for proper brain development.
 
Study reveals first clear link between chronic kidney disease and stroke risk
UCI-led study discovers that reducing renal disease may ultimately improve brain health. 
 
Heal Row 1
UCI Health team receives $13.7 million federal grant to address antibiotic resistance in nursing homes
Novel project brings together diverse investigators to examine six organisms at once. 
 
UCI launches innovative initiative to address diabetes in the Latinx community
Collaboration will focus on prevention, research and treatment of the deadly disease. 
 
Heal Row 2
UCI Health enrolls first patient in expanded access protocol program for ALS drug
A continuing challenge for people living with ALS is that not everyone is eligible to participate in clinical trials due to their disease characteristics or progression.
 
Celebrating a decade of visionary achievement
UCI Gavin Herbert Eye Institute celebrates it’s 10th anniversary! 
 
Heal Row 3
The healthcare industry has climate responsibility: How UCI Health — Irvine is leading the sustainability transformation
One of the main efforts of UCI Health in this regard is the construction of an all-electric healthcare campus: UCI Health – Irvine.
 
Treating the whole person
Bringing integrative healthcare into the mainstream. 
 
Heal 1 Article Rows
UCI Health among nation’s top 10 academic medical centers for high-quality care
Outpatient care network is also ranked one of the top 10 ambulatory systems in the U.S. 
 
Nursing home dementia residents’ care linked to majority presence, UC Irvine-led study finds
Heterogeneous populations are found in most facilities, highlighting need for specialized training. 
 
Research shows people who live to be 90+ with superior thinking skills are resilient to Alzheimer’s pathology in their brains
Age is the primary risk factor for cognitive issues, such as Alzheimer’s, Lewy body disease and other related dementias. Over the past 30 years, the number of people aged 90 and older in the U.S. has nearly tripled, and this number is projected to quadruple in the next four decades.
 
School of Medicine In the News

Dangerous ‘superbugs’ are a growing threat and antibiotics can’t stop their rise. What can?

High-blood pressure at 18 puts you at higher risk for heart attack at midlife

Meet the winners of the 2023 Ig Nobel Prize

Should we be worried about older politicians?

Web searches for self-managed abortions rose after Dobbs decision

Why the rare skin cancer that killed Jimmy Buffet may become more common

Ozempic and Wegovy can also protect your heart

Early-stage trial for Parkinson’s disease therapy shows signs of promisearcers use ‘mini brains’ to look for origin of autism.

Even one drink a day can raise your blood pressure.


 
Calendar

Oct. 28: 15th Annual Orange County Symposium for Cardiovascular Disease Prevention

Oct. 28: Eighth Annual UCI Hematology Symposium

Nov. 3: 2023 Comprehensive Neuroscience & Stroke Symposium

Nov 4: 6th Annual ALL UC Medical Schools Dean’s Reception at AAMC Annual Meeting

Nov. 23 – 24: Thanksgiving Holiday​​​​​

 
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